Mice Sewn Together and Injected With Feces

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Experimenters across the U.S. use mice in horrible experiments in which they induce sepsis—a serious reaction to severe infection—even though these experiments have been scientifically proved to be entirely worthless for understanding the condition in humans
 
Experimenters at the University of Pittsburgh punctured mice's intestines to induce sepsis, causing the animals to suffer and experience painful deaths.
 
Not only are these experiments a total waste of time, money, and life, it also really doesn't get much crueler than what the experimenters do to the precious little animals to induce sepsis:
 
  • They puncture the mice's intestines (you can watch how it's done here) so that feces leak into their stomachs.
  • They sew the mice's bodies together and inject toxins into them.
  • They inject feces from one mouse into the abdomen of another.
  • They insert a stent into the animals' colons so that feces leak out continuously into their bodies.
  • They shove thick tubes down the mice's throats and pump harmful bacteria into their stomachs.
  • They push a "bacterial slurry" into the animals' nostrils.
The procedure shown here, in which two mice are surgically joined, was performed at the University of California–Los Angeles. It's similar to a procedure performed on mice in sepsis experiments.
 
Once sepsis is induced, the animals are destined for an excruciating death. As infection takes over their little bodies, they experience the following:
 
  • Lethargy and disorientation
  • Pain throughout their bodies, with the worst in their abdomens
  • Fever, chills, and diarrhea
  • Difficulty breathing
  • Septic shock when the infection reaches the bloodstream and blood pressure plummets
  • Multi-organ failure
  • Illness so severe that they can't even move
Here's how mind-blowingly pointless this sadistic torture is: In 2013, a landmark study that took a decade to complete found that the results of sepsis experiments done on mice CAN NEVER be applied to humans because the genetic responses to sepsis in the two species are completely different.
 
 
The study was so groundbreaking that even the head of the National Institutes of Health (NIH)—which funds these experiments—wrote, "No wonder drugs designed for the mice failed in humans: they were, in fact, treating different conditions!"
 
We have superior options: A 2015 report issued by an expert working group of researchers listed several cutting-edge methods that could be used instead of failed animal "models" to study sepsis—including in vitro cell cultures, three-dimensional cell cultures to explore the condition's progression in humans, and human genomic information to discover how sepsis affects individuals differently.
 
And still, NIH has spent more than $120 million dollars in tax funds in 2018 alone for these idiotic sepsis experiments on mice. 
 

Tell NIH to stop funding the useless torture of tiny animals.

Mr.
James M.
Anderson
National Institutes of Health

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